Depends what kind of platform you can use.
If you are under Windows, DBD::ODBC will work wonders.
If you `bridge' Windows <-> Unix, you can set up a DBI:
roxyServer on
a windows box using DBD::ODBC, and talk to it from a DBD:
roxy on the Unix
machine (works wonders, allows you to read and write stuff, the only problem
I've had so far with it is that it cannot be used to dump schema via
DBIx::Class::Schema::Loader).
If you just have the Access file on a new windows machine, as far as I can
tell, you can use commercial tools that I don't know quite well, or you can
use a sourceforge project called mdbtools. The main catch with it is that
they don't release very often, the official release does not read a lot
of Access files correctly, and you will have to compile it from CVS.
The end result is not a DBD driver, it's a bit more akward to use. And I
wouldn't use it to write to the database...
KDE also includes keximdb along its koffice suite. I have little experience
with it, but it should be usable to convert access files.