(HELP!?!) Sys.WebForms.PageRequestManagerServerErrorException

[Dave]

My site is starting to give the below area for parameters that have
worked in the past.

Sys.WebForms.PageRequestManagerServerErrorException: String[6]: the
Size property has an invalid size of 0. ScriptResource.axd?
d=dB4YQkvWDiNssE_JaCTk8mvHoCM0qjfGB7ZsGylBVZIjsaW7Q0ogENtN8ZRU9uIZY4tl-0Q-
zZSTsPOyFTrGZeG4luBBAW0_pW5MASgil2WadXfIgKIXmlhzV2eoSF5Q0&t=16ab2387,
line 868 character 13


Anyone have any ideas as to might be causing this? It's not the only
page. Is it possible for the page itself to become corrupt?