invalidating cache on load balancer

[z. f.]

Hi,

i have web app that is running on 3 servers with load balancing.
few pages are cache using the configuration:
<%@ OutputCache Duration="300" VaryByParam="*" Location="Server" %>

i need to be able to invalidate if the managament application changes some specific parameters.

how can i configure this kind of cache to be invalid, so it is created next time?
is there a sample of doing this?
is it possible to have a file dependency with this kind of cache? this should be the most helpful solution.

TIA, z.