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Message: [QUOTE="Jean Dubois, post: 5064428"] It seems there is some misunderstanding here. What I meant with how to "do the equivalent in Python" refered to "reading characters rather than lines". I have written working code myself for another Keithleu which does use RS232 for communication. The problem now is specifically for the new Keithley which doesn't allow RS232 but only USB-communication over usbtmc. So if the "buffer-problem" could be changed by reading characters that would be great. regards, Jean [/QUOTE]