Idela place to create variables for config settings

[Guest]

Hi,

I have a doubt:
Any key defined in the "appsettings" section of the web.config file is
global to the application. Each time the web.config is changed, the
application restarts.

Both together, doesnt it make more sense to create variables to hold values
of these settings in the global.asax itself and store them in application
variables. This way the extra burden of creating them over and over again is
restricted.

If not, is there any disadvantage to it?

Please provide your feedback
lopa